{"id":11098,"date":"2018-06-04T20:15:38","date_gmt":"2018-06-04T20:15:38","guid":{"rendered":"https:\/\/clone.arsacs.com\/arsacs-project-gets-grant-from-italian-ministry-of-health-2\/"},"modified":"2026-03-16T18:09:52","modified_gmt":"2026-03-16T22:09:52","slug":"arsacs-project-gets-grant-from-italian-ministry-of-health-2","status":"publish","type":"post","link":"https:\/\/2026.arsacs.com\/fr\/arsacs-project-gets-grant-from-italian-ministry-of-health-2\/","title":{"rendered":"ARSACS project gets grant from Italian Ministry of Health"},"content":{"rendered":"The Italian Ministry of Health will fund the project \u201cInsight into new therapeutic preclinical strategies in Autosomal Recessive Spastic\nAtaxia of Charlevoix-Saguenay type\u201d presented by:\n\n<div id=\"attachment_99\" style=\"width: 160px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-99\" class=\"wp-image-99 size-thumbnail\" src=\"https:\/\/2026.arsacs.com\/wp-content\/uploads\/2021\/02\/Filippo_Santorelli-150x150-2.jpg\" alt=\"\" width=\"150\" height=\"150\"><p id=\"caption-attachment-99\" class=\"wp-caption-text\">Dr. Filippo M. Santorelli, Molecular Medicine, IRCCS Fondazione Stella Maris, Pisa.<\/p><\/div>\n\n<div id=\"attachment_234\" style=\"width: 160px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-234\" class=\"wp-image-234 size-thumbnail\" src=\"https:\/\/2026.arsacs.com\/wp-content\/uploads\/2021\/02\/DrFrancescaMaltecca-150x150-2.jpg\" alt=\"Dr. Francesca Maltecca\" width=\"150\" height=\"150\"><p id=\"caption-attachment-234\" class=\"wp-caption-text\">Dr. Francesca Maltecca, Neurogenomics Unit, Ospedale San Raffaele, Milan, Italy<\/p><\/div>\n\n<div id=\"attachment_3151\" style=\"width: 160px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-3151\" class=\"size-thumbnail wp-image-3151\" src=\"https:\/\/2026.arsacs.com\/wp-content\/uploads\/2021\/02\/Dr.-Ciofani-150x150-2.jpg\" alt=\"\" width=\"150\" height=\"150\"><p id=\"caption-attachment-3151\" class=\"wp-caption-text\">Dr. Gianni Ciofani, Smart Bio-Interfaces, Istituto Italiano di Tecnologia (IIT), Pontedera (PI)<\/p><\/div>\n\n<div style=\"clear: both;\"><strong>Summary of the Project:<\/strong><\/div>\n\"Autosomal recessive spastic-ataxia of Charlevoix-Saguenay (ARSACS) is a multisystem hereditary ataxia associated with mutations in SACS, encoding sacsin, a protein whose function is only in part understood. Mutations in SACS impair chaperone-mediated protein-folding activity and mitochondrial(mt) dynamics in Sacs knock-out (KO) mice and human ARSACS cells. Our challenge is to find tools capable to reverse sacsin defects in mice and to identify biomarkers of efficacy in clinical trials. We will use a dual approach: we will analyze mt functionality in Purkinje cells needed to fine tuning new treatment opportunities in Sacs KO mice and will seek for prognostic\/predictive biomarkers in patients in order to design new intervention strategies aimed at overcoming brain alterations. To cope with brain alterations in ARSACS and in similar neurological conditions with altered mt functionality, we will also test new nanovectors to easy drug delivery in mutant cells.\"","protected":false},"excerpt":{"rendered":"<p>The Italian Ministry of Health will fund the project \u201cInsight into new therapeutic preclinical strategies in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay type\u201d presented by: Summary of the Project: &#8220;Autosomal recessive spastic-ataxia of Charlevoix-Saguenay (ARSACS) is a multisystem hereditary ataxia associated with mutations in SACS, encoding sacsin, a protein whose function is only in part [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-11098","post","type-post","status-publish","format-standard","hentry","category-24"],"_links":{"self":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11098","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=11098"}],"version-history":[{"count":1,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11098\/revisions"}],"predecessor-version":[{"id":24393,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11098\/revisions\/24393"}],"wp:attachment":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=11098"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=11098"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=11098"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}