{"id":11137,"date":"2018-07-27T21:52:59","date_gmt":"2018-07-27T21:52:59","guid":{"rendered":"https:\/\/clone.arsacs.com\/elucidating-mechanisms-underlying-motor-coordination-rescue-in-a-mouse-model-of-arsacs-dr-alanna-watt-and-dr-anne-mckinney-2\/"},"modified":"2026-03-16T18:10:11","modified_gmt":"2026-03-16T22:10:11","slug":"elucidating-mechanisms-underlying-motor-coordination-rescue-in-a-mouse-model-of-arsacs-dr-alanna-watt-and-dr-anne-mckinney-2-2","status":"publish","type":"post","link":"https:\/\/2026.arsacs.com\/fr\/elucidating-mechanisms-underlying-motor-coordination-rescue-in-a-mouse-model-of-arsacs-dr-alanna-watt-and-dr-anne-mckinney-2-2\/","title":{"rendered":"Elucidating Mechanisms Underlying Motor Coordination Rescue in a Mouse Model of ARSACS- Dr. Alanna Watt and Dr. Anne McKinney"},"content":{"rendered":"Description\nAim 1 Elucidate mechanism underlying MitoQ rescue of motor coordination in Sacs-\/- mice:\n(i)test mitochondrial dynamics and morphology using Mito-tracker administered intracellularly in Purkinje cells in treated and untreated Sacs\u2212\/\u2212 mice, (ii) test mitochondrial function using assays for mitochondrial respiration and energy consumption, and (iii) determine whether MitoQ rescues the abnormal somatodendritic localization of phosphorylated neurofilament in Sacs\u2212\/\u2212 mice.In addition to understanding the mechanism by which MitoQ rescues motor behaviour, the work will continue with the Brais lab to understand how and if a drug recently identified by a drug screen they conducted with V151 improves Purkinje cell morphological and physiological deficits.\n\nAim 2 Identify mechanism(s) underlying Purkinje cell firing deficits in Sacs-\/- mice.\nOver the coming 2018\/2019 year we expect to make substantial advances in understanding the following 5 questions:\n(a) How does MitoQ lead to behavioral improvements in Sacs\u2212\/\u2212 mice?\n(b) Does V151 rescue physiological abnormalities in Sacs\u2212\/\u2212 mice?\n(c) Are glutamate transporters altered in Sacs\u2212\/\u2212 mouse cerebellum?\n(d) Does rescue of firing rate directly ameliorate behavioral phenotype in Sacs\u2212\/\u2212 mice?\n(e) Is zebrin neuroprotective in Sacs\u2212\/\u2212 mouse cerebellum?\n\nDuration : One year\nGrant: $125,000\nContacts:\n\n<div id=\"attachment_132\" style=\"width: 160px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-132\" src=\"https:\/\/2026.arsacs.com\/wp-content\/uploads\/2021\/02\/watt-1-150x150-2.jpg\" alt=\"Dr. Alanna Watt\" width=\"150\" height=\"150\" class=\"size-thumbnail wp-image-132\"><p id=\"caption-attachment-132\" class=\"wp-caption-text\">Dr. Alanna Watt<\/p><\/div>\n\nDr. Alanna Watt, Department of Biology McGill University Bellini Life Sciences Bldg.\n3469 Sir William Osler, Montreal, Quebec Canada H3G 0B1 Office: Rm. 265 | Lab: Rm. 257\nTel: (514)-398-2806; Fax: (514)-398-5069; Email: alanna.watt@mcgill.ca\n\n<div id=\"attachment_186\" style=\"width: 160px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-186\" src=\"https:\/\/2026.arsacs.com\/wp-content\/uploads\/2021\/02\/Anne-McKinney-150x150-2.jpg\" alt=\"Dr. Anne McKinney\" width=\"150\" height=\"150\" class=\"size-thumbnail wp-image-186\"><p id=\"caption-attachment-186\" class=\"wp-caption-text\">Dr. Anne McKinney<\/p><\/div>\n\nDr. Anne McKinney, Department of Pharmacology and Therapeutics, McGill University Bellini Life Sciences Bldg\n3469 Sir William Osler, Montreal, Quebec Canada H3G 0B1\nTel: (514)-398-5685; Fax: (514)-398-2045; Email: anne.mckinney@mcgill.ca","protected":false},"excerpt":{"rendered":"<p>Description Aim 1 Elucidate mechanism underlying MitoQ rescue of motor coordination in Sacs-\/- mice: (i)test mitochondrial dynamics and morphology using Mito-tracker administered intracellularly in Purkinje cells in treated and untreated Sacs\u2212\/\u2212 mice, (ii) test mitochondrial function using assays for mitochondrial respiration and energy consumption, and (iii) determine whether MitoQ rescues the abnormal somatodendritic localization of [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-11137","post","type-post","status-publish","format-standard","hentry","category-research-2018"],"_links":{"self":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11137","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=11137"}],"version-history":[{"count":2,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11137\/revisions"}],"predecessor-version":[{"id":24429,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11137\/revisions\/24429"}],"wp:attachment":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=11137"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=11137"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=11137"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}