{"id":11399,"date":"2019-12-07T18:53:58","date_gmt":"2019-12-07T23:53:58","guid":{"rendered":"https:\/\/clone.arsacs.com\/targeting-deregulated-calcium-homeostasis-as-potential-therapeutic-option-for-arsacs-dr-francesca-maltecca\/"},"modified":"2026-03-16T18:11:39","modified_gmt":"2026-03-16T22:11:39","slug":"targeting-deregulated-calcium-homeostasis-as-potential-therapeutic-option-for-arsacs-dr-francesca-maltecca-2","status":"publish","type":"post","link":"https:\/\/2026.arsacs.com\/fr\/targeting-deregulated-calcium-homeostasis-as-potential-therapeutic-option-for-arsacs-dr-francesca-maltecca-2\/","title":{"rendered":"Targeting deregulated calcium homeostasis as potential therapeutic option for ARSACS -Dr. Francesca Maltecca"},"content":{"rendered":"<p>The major aims of this project\nare:<\/p>\n\n\n\n<p>1) to evaluate the functional\nrole of sacsin at the synaptic level, in particular its involvement in the\ncontrol of calcium fluxes in Purkinje neurons at the postsynaptic space;<\/p>\n\n\n\n<p>2) to strengthen the evidence\nof efficacy of an off-label drug regulating calcium homeostasis in ARSACS, by\nconducting a preclinical trial at post- symptomatic stage in Sacs-\/- mice with\na chronic treatment;<\/p>\n\n\n\n<p>3) to dissect the mechanism by which this drug rescues ataxia and Purkinje cell degeneration in Sacs-\/- mice, by evaluating effects on deregulated calcium homeostasis, NF bundling or faulty mitochondrial transport, integrated with multi-omics approaches.<\/p>\n\n\n\n<p>Duration: One year <\/p>\n\n\n\n<p>Funding : $100,000<\/p>\n\n\n\n<p>Contact: <\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/2026.arsacs.com\/wp-content\/uploads\/2021\/02\/DrFrancescaMaltecca.jpg\" alt=\"Dr. Francesca Maltecca\" class=\"wp-image-234\"\/><\/figure>\n\n\n\n<p>Dr. Francesca Maltecca ,  Ospedale San Raffaele, Milan Italy.<\/p>\n\n\n\n<p>email <a rel=\"noreferrer noopener\" href=\"mailto:maltecca.francesca@unisr.it\" target=\"_blank\">maltecca.francesca@unisr.it<\/a> <\/p>\n\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>The major aims of this project are: 1) to evaluate the functional role of sacsin at the synaptic level, in particular its involvement in the control of calcium fluxes in Purkinje neurons at the postsynaptic space; 2) to strengthen the evidence of efficacy of an off-label drug regulating calcium homeostasis in ARSACS, by conducting a [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-11399","post","type-post","status-publish","format-standard","hentry","category-research-2019"],"_links":{"self":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=11399"}],"version-history":[{"count":2,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11399\/revisions"}],"predecessor-version":[{"id":24571,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11399\/revisions\/24571"}],"wp:attachment":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=11399"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=11399"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=11399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}