{"id":22600,"date":"2025-09-24T12:34:25","date_gmt":"2025-09-24T16:34:25","guid":{"rendered":"https:\/\/www.arsacs.com\/?p=22600"},"modified":"2026-03-16T18:18:09","modified_gmt":"2026-03-16T22:18:09","slug":"developing-conditional-mouse-models-and-new-approaches-to-treating-arsacs-dr-stefan-strack-2-2","status":"publish","type":"post","link":"https:\/\/2026.arsacs.com\/fr\/developing-conditional-mouse-models-and-new-approaches-to-treating-arsacs-dr-stefan-strack-2-2\/","title":{"rendered":"&#8220;Developing conditional mouse models and new approaches to treating ARSACS&#8221; &#8211; Dr. Stefan Strack"},"content":{"rendered":"<p>The <em>Sacs<\/em> knock-out (KO) mouse is a faithful model of ARSACS, displaying ataxia, muscle weakness, cerebellar degeneration, and, as we have recently shown, learning and memory deficits. With this proposal, we seek to pharmacologically rescue motor- and cognitive phenotypes in the <em>Sacs<\/em> KO model of ARSACS with a drug that raises levels of a second messenger (cAMP) in the brain and that is currently in phase 2 and phase 3 clinical trials for two neurodevelopmental disorders. Second, we propose to develop gene therapy for ARSACS. Third, we have generated a conditional <em>Sacs<\/em> KO model, which we will use to pinpoint where and when <em>Sacs<\/em> loss-of-function causes the spectrum of ARSACS symptoms.\u00a0<\/p>\n<p>\u00a0<\/p>\n<p>Grant: $100,000<\/p>\n<p style=\"text-align: left;\">Duration: one year<\/p>\n<p>\u00a0<\/p>\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\" style=\"grid-template-columns:19% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"180\" src=\"https:\/\/2026.arsacs.com\/wp-content\/uploads\/2023\/09\/Strack.jpg\" alt=\"\" class=\"wp-image-19043 size-full\"\/><\/figure><div class=\"wp-block-media-text__content\">\n<p>Dr. Stefan Strack, Department Neurosciences @Pharmacology<br>University of Iowa Carver College of Medicine<br>2-452 BSB, 51 Newton Rd. Iowa City, IA 52242<br>stefan-strack@uiowa.edu<\/p>\n\n\n\n<p>Contact:   <a href=\"mailto:stefan-strack@uiowa.edu\">stefan-strack@uiowa.edu<\/a><\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>The Sacs knock-out (KO) mouse is a faithful model of ARSACS, displaying ataxia, muscle weakness, cerebellar degeneration, and, as we have recently shown, learning and memory deficits. With this proposal, we seek to pharmacologically rescue motor- and cognitive phenotypes in the Sacs KO model of ARSACS with a drug that raises levels of a second [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-22600","post","type-post","status-publish","format-standard","hentry","category-current"],"_links":{"self":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22600","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=22600"}],"version-history":[{"count":7,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22600\/revisions"}],"predecessor-version":[{"id":25124,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22600\/revisions\/25124"}],"wp:attachment":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=22600"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=22600"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=22600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}