{"id":22614,"date":"2025-09-24T12:27:22","date_gmt":"2025-09-24T16:27:22","guid":{"rendered":"https:\/\/www.arsacs.com\/?p=22614"},"modified":"2026-03-16T18:18:04","modified_gmt":"2026-03-16T22:18:04","slug":"a-transcriptomic-approach-to-drug-discovery-against-arsacs-dr-nicolas-dupre-2","status":"publish","type":"post","link":"https:\/\/2026.arsacs.com\/fr\/a-transcriptomic-approach-to-drug-discovery-against-arsacs-dr-nicolas-dupre-2\/","title":{"rendered":"“A transcriptomic approach to drug discovery against ARSACS ” – Dr. Nicolas Dupr\u00e9"},"content":{"rendered":"

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This project aims to discover new therapeutic targets and potential drugs for ARSACS by combining blood samples from patients with advanced iPSC (induced pluripotent stem cell) technology and artificial intelligence (AI). The team will analyze gene expression patterns in blood samples, patient-derived iPSCs, and genetically corrected control cells to identify common disease mechanisms across different SACS<\/em> mutations. Using Oncocross's RAPTOR AI platform, approximately 25,000 drug candidates will be screened to find compounds that could reverse ARSACS-associated cellular changes.<\/p>\n\n\n\n

Grant: $25,000<\/p>\n\n\n\n

Duration : one year<\/p>\n\n\n\n

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Dr. Nicolas Dupr\u00e9
LOEX, Aile-R, R-111
H\u00f4pital de l'Enfant-J\u00e9sus
1401, 18e Rue
Qu\u00e9bec (Qu\u00e9bec) G1J 1Z4<\/p>\n\n\n\n

Contact:\u00a0\u00a0nicolas.dupre.med@ssss.gouv.qc.ca<\/a><\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

This project aims to discover new therapeutic targets and potential drugs for ARSACS by combining blood samples from patients with advanced iPSC (induced pluripotent stem cell) technology and artificial intelligence (AI). The team will analyze gene expression patterns in blood samples, patient-derived iPSCs, and genetically corrected control cells to identify common disease mechanisms across different SACS mutations. […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-22614","post","type-post","status-publish","format-standard","hentry","category-current"],"_links":{"self":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22614","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=22614"}],"version-history":[{"count":6,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22614\/revisions"}],"predecessor-version":[{"id":25117,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22614\/revisions\/25117"}],"wp:attachment":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=22614"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=22614"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=22614"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}