{"id":22714,"date":"2025-09-25T14:33:40","date_gmt":"2025-09-25T18:33:40","guid":{"rendered":"https:\/\/www.arsacs.com\/?p=22714"},"modified":"2026-03-16T18:18:22","modified_gmt":"2026-03-16T22:18:22","slug":"scalable-therapeutic-testing-in-the-arsacs-mouse-dr-justin-wolter","status":"publish","type":"post","link":"https:\/\/2026.arsacs.com\/fr\/scalable-therapeutic-testing-in-the-arsacs-mouse-dr-justin-wolter\/","title":{"rendered":"“Scalable therapeutic testing in the ARSACS mouse” – Drs Justin Wolter & Huaxia Wang"},"content":{"rendered":"

Our project aims to accelerate drug discovery for ARSACS by using advanced single nucleus RNA sequencing (snRNAseq) to test 8 therapeutic candidates in the ARSACS mouse model (including ongoing studies led by Drs. Gentil\/Durham, and Drs. Lim\/Schmahmann). Unlike traditional methods that rely on variable and lengthy behavioral tests, our approach directly measures molecular and cellular changes in key brain cell types affected by ARSACS, providing more precise and scalable assessments of drug effects. By identifying how each drug alters gene expression and cell populations linked to disease progression, we can prioritize the most promising treatments for further development. This work aims to streamline and improve preclinical testing, ultimately helping to bring effective therapies to the ARSACS community faster.<\/span><\/p>\n

Financement: 100 000$<\/p>\n

Ce projet a \u00e9t\u00e9 financ\u00e9 conjointement avec le Richardson Trust Fund qui a contribu\u00e9 50 000$ \u00e0 ce projet.\u00a0<\/strong><\/p>\n

Dur\u00e9e : 1e ann\u00e9e d'un projet de trois ans<\/p>\n

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Dr Justin Wolter
425 Henry Mall
Madison, WI
53706
USA<\/p>\n\n\n\n

Coordonn\u00e9es:\u00a0wolter4@wisc.edu<\/a><\/p>\n\n\n\n

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Dre Huaxia Wang
425 Henry Mall
Madison, WI
53706
US<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

Our project aims to accelerate drug discovery for ARSACS by using advanced single nucleus RNA sequencing (snRNAseq) to test 8 therapeutic candidates in the ARSACS mouse model (including ongoing studies led by Drs. Gentil\/Durham, and Drs. Lim\/Schmahmann). Unlike traditional methods that rely on variable and lengthy behavioral tests, our approach directly measures molecular and cellular […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[],"class_list":["post-22714","post","type-post","status-publish","format-standard","hentry","category-projets-de-recherche"],"_links":{"self":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22714","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=22714"}],"version-history":[{"count":25,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22714\/revisions"}],"predecessor-version":[{"id":25140,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22714\/revisions\/25140"}],"wp:attachment":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=22714"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=22714"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=22714"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}