{"id":22750,"date":"2025-09-25T11:15:15","date_gmt":"2025-09-25T15:15:15","guid":{"rendered":"https:\/\/www.arsacs.com\/?p=22750"},"modified":"2026-03-16T18:18:13","modified_gmt":"2026-03-16T22:18:13","slug":"targeting-scn4b-as-a-therapy-to-rescue-ataxia-in-a-mouse-model-of-arsacs-structural-determination-of-sacsin-dr-r-anne-mckinney","status":"publish","type":"post","link":"https:\/\/2026.arsacs.com\/fr\/targeting-scn4b-as-a-therapy-to-rescue-ataxia-in-a-mouse-model-of-arsacs-structural-determination-of-sacsin-dr-r-anne-mckinney\/","title":{"rendered":"“Targeting Scn4b as a therapy to rescue ataxia in a mouse model of ARSACS\u201d – Dr. R. Anne McKinney"},"content":{"rendered":"

<\/h1>\n\n\n

As cerebellar dysfunction is thought to underlie ARSACS pathology, work from the <\/span>McKinney lab focus on identifying novel disease-causing mechanisms in a mouse model of ARSACS, as well as implementing new therapeutic approaches to ameliorate cerebellar function and motor deficits. We have identified promising new dysregulated gene products using RNA-Seq and bioinformatics and are pursuing these experimentally. We are using a multidisciplined approach combining electrophysiology, molecular and biochemical approaches to understand the mechanisms why certain Purkinje cells are more vulnerable to die. Based on our findings we are now testing novel therapeutic approaches to prevent Purkinje cell death and prevent ataxia.<\/p>\n

Grant: $98,000<\/p>\n

Duration : one year<\/p>\n

\u00a0<\/span><\/p>\n\n\n

\"\"<\/figure>
\n

Dr. R. Anne McKinney
Dept Pharmacology and Therapeutics
Bellini Life Science Building, Room 167
3649 Sir William Osler, Montreal, QC
H3G 0B1<\/p>\n\n\n\n

Contact:   anne.mckinney@mcgill.ca<\/a> <\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

As cerebellar dysfunction is thought to underlie ARSACS pathology, work from the McKinney lab focus on identifying novel disease-causing mechanisms in a mouse model of ARSACS, as well as implementing new therapeutic approaches to ameliorate cerebellar function and motor deficits. We have identified promising new dysregulated gene products using RNA-Seq and bioinformatics and are pursuing […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-22750","post","type-post","status-publish","format-standard","hentry","category-current"],"_links":{"self":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22750","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=22750"}],"version-history":[{"count":9,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22750\/revisions"}],"predecessor-version":[{"id":25129,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22750\/revisions\/25129"}],"wp:attachment":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=22750"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=22750"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=22750"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}