{"id":22784,"date":"2025-09-25T14:29:23","date_gmt":"2025-09-25T18:29:23","guid":{"rendered":"https:\/\/www.arsacs.com\/?p=22784"},"modified":"2026-03-16T18:18:15","modified_gmt":"2026-03-16T22:18:15","slug":"advanced-mri-studies-to-achieve-microstructural-insight-and-identifyimaging-biomarkers-in-arsacs-dre-roberta-la-piana","status":"publish","type":"post","link":"https:\/\/2026.arsacs.com\/fr\/advanced-mri-studies-to-achieve-microstructural-insight-and-identifyimaging-biomarkers-in-arsacs-dre-roberta-la-piana\/","title":{"rendered":"“Advanced MRI studies to achieve microstructural insight and identifyimaging biomarkers in ARSACS ” – Dre Roberta La Piana"},"content":{"rendered":"

The involvement of the corticospinal tracts (CST) and cerebellum are the disease hallmarks of ARSACS. Previous radiological studies documented the presence of specific findings which were described as\u00a0linear hypointensities in T2-weighted images at the level of the pons<\/b>. <\/span>This finding has become very suggestive of ARSACS when seen in brain MRIs; however, its significance is still unclear, with some studies proposing that it could be due to abnormal developmental of the brain. We aim to use\u00a0advanced Magnetic Resonance (MR) techniques<\/b>\u00a0that combine diffusion and magnetization transfer imaging to\u00a0clarify the properties of the corticospinal tract<\/b> in individuals with ARSACS and thus clarify the meaning of the pontine findings. Additionally, we aim to\u00a0confirm<\/b>\u00a0the presence of similar findings in the\u00a0SACS<\/i>-mutant mouse model<\/b>, to verify its usefulness as a\u00a0pre-clinical model<\/b>\u00a0for future therapeutic options.\u00a0<\/p>\n

Financement : 95 420$<\/p>\n

Ce projet a \u00e9t\u00e9 financ\u00e9 conjointement avec le Richardson Trust Fund qui a contribu\u00e9 50 000$\u00a0 \u00e0 ce projet.\u00a0<\/strong><\/p>\n

Dur\u00e9e: Un an<\/p>\n\n\n

\"\"<\/figure>
\n

Dre Roberta La Piana
Institut Neurologique de Montr\u00e9al
3801 rue University
H3A 2B4 Montreal, QC<\/p>\n\n\n\n

Coordonn\u00e9es: roberta.lapiana@mcgill.ca<\/a><\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

The involvement of the corticospinal tracts (CST) and cerebellum are the disease hallmarks of ARSACS. Previous radiological studies documented the presence of specific findings which were described as\u00a0linear hypointensities in T2-weighted images at the level of the pons. This finding has become very suggestive of ARSACS when seen in brain MRIs; however, its significance is […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[],"class_list":["post-22784","post","type-post","status-publish","format-standard","hentry","category-projets-de-recherche"],"_links":{"self":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22784","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=22784"}],"version-history":[{"count":6,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22784\/revisions"}],"predecessor-version":[{"id":25132,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22784\/revisions\/25132"}],"wp:attachment":[{"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=22784"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=22784"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/2026.arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=22784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}