Phenotyping ARSACS in Vitro Using hiPSCs Reprogrammed from Patients and Differentiated into Motor Neurons and Schwabb cells – Dr. François Berthod

The objectives are to: (1) develop and characterize a 3D in vitro human model constituted of fibroblasts, motor neurons, Schwann cells and myoblasts that recapitulate the ARSACS phenotype at the motor neuron scale, (2) determine whether the ARSACS phenotype is homogeneous between different patients in vitro. Duration: one year Grant: $80,000 contact: Dr. François Berthod, professor department of Surgery Faculty of medicine of University Laval tel: 418-990-8255 x61705; courriel: francois.berthod@fmed.ulaval.ca